English
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Research Interests
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----- Welcome to Our Lab from Oversea Countries ----- Our research includes application of optical spectroscopic and nuclear magnetic resonance spectroscopic techniques to study metabolic regulation in normal, trained and untraiened tissues in vivo. Recently, we also use cell culture system to determine a specific protein-protein interaction that would affect muscle mitochondrial respiration and bioenergetics. Also we put forces on the regulation of mitochondrial biogenesis induced by exercise and natural nutrients. Our current research focuses on 1) developing of detection technique to monitor/map tissue oxygenation and metabolite levels in vivo, 2) investigation of the cellular response to limiting oxygen and the control of oxidative phosphorylation in skeletal muscle and myocardium, 3) determining the structure and function of proteins, especially hemeprotein family such as myoglobin, hemoglobin and neuroglobin in the cell, 4) assess the effect of exercise and nutrition aid on cellular oxidative stress and cell function, 5) investigation the reguralartion of mitochondrial biogenesis by exercise and nutrients, and 6) developing training methods to improve athlete's physical conditioning. etc... More information about our reasearch (click here) --- --- --- --- --- Welcome to Join with Our Muscle Research ! --- --- --- --- --- --- It is open for an application to our graduate school. If you have any questions to apply our graduate school program (master and doctoral programs), postdoctoral fellowship and research collaborations, DO NOT hesitate to contact us via e-mail. Currently, Indonesian researcher has joined with us to get PhD. We will appreciate that you join our research... PLEASE NOTE*: For an Applicants to the MEXT scholarship We appreciate for the applicants to the MEXT scholarship from oversea countries. Nowadays, every year, there are several applicants to the MEXT scholarship for joining in my laboratory as a candidate of PhD course. If you are really interested in our research, please ask us about your plan. Unfortunately, someone does not seem to have enough knowledge and skills to proceed scientific workout during the course. We should require the applicants to have enough biochemical and biological knowledge in order to complete the research activity within the standardized course years (3 yrs). |
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Research Areas
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| Exercise physiology, Applied Physiology, Biology, Cellular metabolism, Cardiovascular response, Free radical, Hemeprotein, Oxygen transport to tissue, Sports and clinical Nutrition |
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Supervisor
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| Kazumi MASUDA, Ph.D., Professor < Brief C.V. > PhD in Exercise Science from Univ. of Tsukuba, Japan (1999.Mar), Research Associate at Center for Tsukuba Advanced Research Alliance, Univ. of Tsukuba, Japan (~2001.Dec), Associate Professor in Exercise Physiology at Faculty of Education, Kanazawa Univ., Japan (~2009.Mar), Professor in Exercise Physiology at Faculty of Human Sciences, Kanazawa Univ., Japan (2009.Apr~) |
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Laboratory Personnel & Graduate Groups |
| Dr. Tsubasa Shibaguchi, PhD, International backbone Education Institute, Kanazawa Univ., Japan Dr. Yudai Nonaka, PhD, International backbone Education Institute, Kanazawa Univ., Japan Mr. Rikuhide Koma, MSc, Graduate school of Natural Sci, Kanazawa Univ., Japan Mrs. Rie Yamada, Technical Assistant, Faculty of Human Sci, Kanazawa Univ., Japan Others... (some undergraduate students) |
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Collaborators
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| Dr. Hisashi Takakura, Doshisya Univ, Japan Dr. Yasuro Furuichi, Tokyo Metropolitan Univ., Japan Dr. Tatsuya Yamada, MSc, Research Assistant, Johns Hopkins University, School of Medicine, MD, USA Dr. Ronald DR Hamidie, MSc, MD, Faculty of Sport and Health Education, Univ. Pendidikan Indonesia Prof. Thomas Jue, Univ. of California Davis, USA Dr. Ulrike Kreutzer, Univ. of California Davis, USA Dr. Rie Ishizawa, Research Assistant, Waseda Univ., Japan Dr. Yoshiteru Hanai, Nagoya Institute of Technology, Japan Dr. Yutaka Kano, Univ. of Electro-Communications, Japan Dr. Takeshi Hashimoto, Ritsumeikan Univ., Japan Dr. Nobumasa Iwanaka, Ritsumeikan Univ., Japan Prof. Koji Ishida, Nagoya Univ., Japan Prof. Hiroshi Akima, Nagoya Univ., Japan Prof. Keisyo Katayama, Nagoya Univ., Japan Prof. Satoshi Iwase, Aichi Medical Univ., Japan Prof. Aki Hirayama, Tsukuba Univ. of Technology, Japan Dr. Kai Tanabe, Komazawa Women Univ., Japan Prof. Thomas Reilly, Liverpool John Moores Univ., UK (passed on June 11, 2009) |
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Recent Publications
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| 1. | 65. Hamidie DRR, Shibaguchi T, Yamada T, Koma R, Ishizawa R, Saito Y, Hosoi T and Masuda K: Curcumin induces mitochondrial biogenesis by increasing cyclic AMP levels via phosphodiesterase 4A inhibition in skeletal muscle. Br J Nutr 126: 1642-1650, 2021. |
| 2. | Koma R, Shibaguchi T, Pérez-López C, Oka T, Jue T, Takakura H and Masuda KCA: Localization of myoglobin in mitochondria: implication in regulation of mitochondrial respiration in rat skeletal muscle. Physiol Rep 9:e14769, 2021. |
| 3. | Yamada T, Takakura H, Jue T, Hashimoto T, Ishizawa R, Furuichi Y, Kato Y, Iwanaka N and Masuda K: Myoglobin and the Regulation of Mitochondrial Respiratory Chain Complex IV. Journal of Physiology 594: 483-495, 2016. |
| 4. | Hamidie DRR, Yamada T, Ishizawa R, Saito Y and Masuda K: Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels. Metabolism 64: 1334-1347, 2015. |
| 5. | Yamada T, Furuichi Y, Takakura H, Hashimoto T, Hanai Y, Jue T and Masuda K: Interaction between myoglobin and mitochondria in rat skeletal muscle. J Appl Physiol 114: 490-497, 2013. |
| 6. | See more information on the Publication page. |
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Go to Japanese site
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